1、从海洋等来源的特境微生物“talented strains”资源中发掘
创新药物先导化合物：
利用生物学与化学相结合的集成筛选方法，从海洋等特殊环境微生物中筛选并发现具有重要生物活性的药物先导化合物及药源微生物“talented strains”新资源。
2、非“talented strains”向“talented strains”的转化研究：
利用化学诱导和共培养技术，激活微生物中表达次生代谢产物的沉默基因，转化“非天才菌株”为“天才菌株”。
3、天然药物的优化：
对具有重要生物活性的微生物天然产物进行结构修饰，探讨构效关系，获得临床候选药物。
在研课题“浒苔
共
附生微生物及其含氮、卤代等克生活性产物研究
”（No. 41376148, 2014–2017，国家自然科学基金）“
环境胁迫增加
海洋真菌的化学多样性研究
”（No. 21172204, 2012–2015，国家自然科学基金）“深海微生物活性物质的发现及其生物合成技术”
（No. 2012AA092104-1, 2012–2015，863子课题）“海洋微生物次生代谢产物
的生理活性及其机制
”（No. 2010CB833804, 2010–2014, 973子课题）“逆转多药耐药抗乳腺癌化合物HDZ-137成药性评价”（No. 2011AA09070106, 2011–2014，863课题）。
教育背景1981–1985年：武汉大学化学系，毕业并获得理学学士学位。
1985–1988年：武汉大学化学系，毕业并获得理学硕士学位，发表论文1篇（现为SCI期刊）。
1997–2001年：中科院昆明植物研究所，毕业并获得理学博士学位，发表SCI论文14篇（第一作者SCI论文8篇）。
个人经历1988–2003年：云南师范大学化学系，从事有机化学科研与教学工作，任讲师、副教授、教授；承担国家、省级课题各1项，发表论文15篇，主编教参1部。
2001–2003年：中国科学院上海有机化学研究所博士后，从事活性产物喷脑皂甙元及其衍生物合成研究，申请中国发明专利3项（授权2项）。
2003–今：中国海洋大学医药学院，从事海洋天然产物化学的科研与教学工作，任教授、硕导、博导。承担973、863、NSFC等国家级课题15项，发表SCI论文115篇，申请中国发明专利25项（授权12项）。
2017年12月8日中国海洋大学朱伟明教授应邀作客“未央导师论坛”，做了题为《特境微生物来源的活性产物研究》的报告。[1]
代表性论文2015
1.Fandong Kong,et al,
Weiming Zhu
. New a-glucosidase inhibitors from a marinesponge-derived fungus,Aspergillussp. OUCMDZ-1583.RSC Adv.
2015
, 5(84), 68852–68863.（影响因子3.84
）2.Liping Wang,et al,
Weiming Zhu
.Biomimetic semi-synthesis of fradcarbazole A and its analogues.Tetrahedron2015, online, DOI: 10.1016/j.tet.2015.08.063.CuitingLv, et al, Kui Hong,
Weiming Zhu
,Ruohua Chen,Caiguo Huang,Ophiobolin O isolated fromAspergillusustusinduces G1 arrest of MCF-7 cells through interaction with AKT/GSK3β/Cyclin D1 signaling.Mar Drugs
2015
, 13(1): 431–443.2014
1.Peng Fu, et al,
Weiming Zhu
.Acyclic Congeners fromActinoalloteichuscyanogriseusProvide Insights into Cyclic Bipyridine Glycoside Formation.Org Lett
2014
, 16(16): 4264–4267.（影响因子6.32）
2.Peng Fu,et al,
Weiming Zhu
.Cyanogramide with a NewSpiro[indolinonepyrroloimidazole]Skeleton fromActinoalloteichuscyanogriseus.Org Lett
2014
,16(14): 3708–3711.3.Fandong Kong,et al,
Weiming Zhu
*.Thiodiketopiperazines from the marine-derived fungusPhomasp. OUCMDZ-1847.J NatProd
2014
, 77 (1): 132–137.4.Kunlai Sun,et al,
Weiming Zhu
*. Indolediterpenoids and isocoumarin from the fungus,Aspergillusflavus, isolated from the prawn,Penaeusvannamei.Mar Drugs
2014
, 12(7): 3970–3981.5.Yi Wang,et al,
Weiming Zhu
*. Phenolic Polyketides from the Co-Cultivation of Marine-DerivedPenicilliumsp. WC-29-5 andStreptomycesfradiae007.Mar Drugs
2014
, 12(4): 2079–2088.6.Pei Wang,et al,Weiming Zhu*.Alkaloids from the mangrove-derived actinomyceteJishengellaendophytica161111.
Mar Drugs
2014
, 12(1):477–490.7.Tonghan Zhu,et al,
Weiming Zhu
*. New rubrolides from the marine-derived fungusAspergillusterreusOUCMDZ-1925.J Antibiot
(Tokyo).2014
, 67(4): 315–318.8.王立平，庄以彬，孙坤来,
朱伟明
. PKC-412卤代衍生物的合成及细胞毒活性研究.有机化学
,2014
, 34(8): 1603–1608.2013
1.Yiguang Zhu, et al,
Weiming Zhu
, and Changsheng Zhang, Insights into caerulomycin A biosynthesis: atwo-component monooxygenase CrmH-catalyzed oxime formation.J. Am. Chem. Soc.,2013
, 135(50): 18750–18753（影响因子10.68）
2.Yaqin Fan, et al,
Weiming Zhu
,Indole-diterpenoids with anti-H1N1 activity from the aciduric fungusPenicillium camembertiOUCMDZ-1492.J Nat Prod
2013
, 76(7): 1328–1336.（影响因子3.17）
3.Wenxia Sun, et al,
Weiming Zhu
,and Caiguo Huang, Ophiobolin-O reverses adriamycin resistance via cell cycle arrest and apoptosis sensitization in adriamycin-resistant human breast carcinoma (MCF-7/ADR) cells.Mar Drugs
2013
, 11(11): 4570–4584.4.Pei Wang, et al,
Weiming Zhu
,Diketopiperazine derivatives from the marine-derived actinomyceteStreptomycessp. FXJ7.328.Mar Drugs
2013
, 11(4): 1035–1049.（影响因子3.98）
5.Liping Wang,
Weiming Zhu
, Versicolactones A and B: total synthesis and structure revision.Tetrahedron Lett
2013
, 54(49): 6729–6731（影响因子2.68）
6.Peng Fu, et al,
Weiming Zhu
, α-Pyrones from the marine-derived actinomyceteNocardiopsisdassonvillei subsp.dassonvilleiXG-8-1.RSC Adv
2013
, 3(43): 20726–20731.（影响因子2.56）
7.Jinkai Zheng, et al,
Weiming Zhu
, Antimicrobial ergosteroids and pyrrole derivatives from halotolerantAspergillus flocculosusPT05-1 cultured in a hypersaline medium.Extremophiles
2013
, 17(6): 963-971.（影响因子2.20）
8.Yi Wang, et al,
Weiming Zhu
, Developments around the bioactive diketopiperazines: a patent review.Expert OpinTher Pat.
2013
, 23(11): 1415–1433.（影响因子3.52）
9.赵成英，朱统汉,
朱伟明
. 2010—2013之海洋微生物新天然产物.有机化学
,2013
,33(6): 1195–1234.2012
1.Peng Fu, et al,
Weiming Zhu
, New indolocarbazoles from a mutant strain of the marine-derived actinomyceteStreptomyces fradiae007M135.OrgLett
2012
, 14(24): 6194–6197.（影响因子6.14）
2.Peng Fu, et al,
Weiming Zhu
,Streptocarbazoles A and B, two novel indolocarbazoles from the marine-derived actinomycete strainStreptomycessp. FMA.OrgLett
2012
, 14(9): 2422–2425.3.Yiguang Zhu,et al,
Weiming Zhu
,Changsheng Zhang, Identification of Caerulomycin A Gene Cluster Implicates a Tailoring Amidohydrolase.Org. Lett.
2012
, 14(11):2666–2669.4.Junfeng Wang, et al,
Weiming Zhu
, Cytotoxic Polyphenols from the FungusPenicillium expansum091006 endogenous with Mangrove PlantExcoecaria agallocha.Planta Med
2012
,78(17): 1861–1866.（影响因子2.15）
2011
1.Peng Fu,et al,
Weiming Zhu
,Cyclic bipyridine glycosides from the marine-derived actinomyceteActinoalloteichuscyanogriseusWH1-2216-6,OrgLett
2011
, 13(22): 5948–5951.2.Yibin Zhuang, et al,
Weiming Zhu
. New quinazolinone alkaloids within rare amino acid residue from coral-associated fungus,Aspergillus versicolorLCJ-5-4,OrgLett
2011
, 13 (5): 1130–1133.3.Peng Fu, et al,
Weiming Zhu
,α-Pyrones and diketopiperazine derivatives from the marine-derived actinomyceteNocardiopsis dassonvilleiHR10-5,JNatProd
2011
, 74(10):2219–2223.4.Hui Wang,et al,
Weiming Zhu
, Anti-influenza virus polyketides from the acid-tolerant fungusPenicillium purpurogenumJS03-21,JNatProd
2011
, 74(9):2014–2018.5.Peng Fu, et al,
Weiming Zhu
, Cytotoxic bipyridines from the marine-derived actinomyceteActinoalloteichus cyanogriseusWH1-2216-6,JNatProd
2011
, 74(8): 1751–1756.6.Yibin Zhuang, et al,
Weiming Zhu
, Cyclopeptides and polyketides from coral-associated fungus,Aspergillus versicolorLCJ-5-4,Tetrahedron
, 2011
, 67(37): 7085–7089.7.Zhihong Xu, et al,
Weiming Zhu
.Antifungal quinazolinones from marine-derivedBacillus cereusand their preparation,BioorgMedChemLett
2011
, 21(13): 4005–4007.8.
朱伟明
,王俊锋，海洋真菌生物活性物质研究之管见，菌物学报，2011
, 30(2): 218–228.2010
9.Jinkai Zheng, et al,
Weiming Zhu
,Cyclic tripeptides from the halotolerant fungusAspergillus sclerotiorumPT06-1,JNatProd
2010
, 73(6): 1133–1137.10.Zhenyu Lu,et al,Kui Hong,
Weiming Zhu
.Cytotoxic polyphenols from the marine-derived fungusPenicillium expansum,J NatProd
2010
, 73(5): 911–914.2009
1.Jinkai Zheng,et al,
Weiming Zhu
, Novel cyclic hexapeptides from marine-derived fungus,Aspergillus sclerotiorumPT06-1,Org Lett
2009
, 11(22): 5262–5265.2.Zhenyu Lu, et al,
Weiming Zhu
, Sesquiterpenoids and benzofuranoids from the marine-derived fungusAspergillus ustus094102,JNatProd
2009
, 72(10): 1761–1767.3.Lin Duan, et al,
Weiming Zhu
. Cytotoxic and antioxidative phenolic compounds from the traditional Chinese medicinal plant,Myristica fragrans,Planta Med
2009
, 75(11): 1241–1245.2008
1.Hongwen Tao, et al,
Weiming Zhu
, Resin glycoside constituents ofIpomoea pes-caprae(beach morning glory),JNatProd
2008
, 71(12): 1998–2003.2.Min Zhang, et al,
Weiming Zhu
, Cytotoxic alkaloids and antibiotic nor-dammarane triterpenoids from marine-derived fungusAspergillus sydowi.JNatProd
2008
, 71 (6): 985–989.3.Zhenyu Lu, et al,
Weiming Zhu
, Citrinin dimers from the halotolerant fungusPenicillium citrinumB-57,JNatProd
2008,
71 (4): 543–546.4.Zhenjian Lin, et al,
Weiming Zhu
, Polyketides fromPenicilliumsp.JP-1, anendophytic fungus associated withthe mangrove plantAegiceras corniculatum,Phytochemistry
2008
, 69(5): 1273–1278.（影响因子3.35）
5.Fazuo Wang, et al,
Weiming Zhu
, Seven new prenylated indole diketopiperazine alkaloids from holothurian-derived fungusAspergillus fumigatus,Tetrahedron
2008
, 64(34): 7986–7991.（影响因子3.02
）6.Fazuo Wang, et al,
Weiming Zhu
, Six new ergosterols from the marine-derived fungusRhizopussp.Steroids
2008
,73(1): 19–26.（（影响因子2.83）
）7.Yapeng Zhang, et al,
Weiming Zhu
,Isolation, structure elucidation, and antimycobacterial properties of dimeric naphtho-gamma-pyrones from the marine-derived fungusAspergillus carbonarius,Chem Biodiversity
2008
, 5(1):93–100.
