孙宝林

时间:2023-11-15 20:59:58编辑:莆田seo君
人物经历

1986年牡丹江师范学院学士;

1989年中科院遗传所硕士;

1999年密歇根州立大学博士。

研究方向

重要致病细菌群体感应与生物膜发育及致病机理;细菌非编码小RNA调控的细胞行为。详情请见实验室主页sunlab点ustc点edu点cn。

主要贡献

主要在研课题:

1. 中国科学院“百人计划”专项,2004.01–2007.12,资助金额:270万。

2. 国家“十一五”科技重大专项“艾滋病和病毒性肝炎等重大传染病防治”子课题“结核病靶标研究”,2008.10–2011.05,资助金额:315万。

3. 中国科学院知识创新工程“结核分枝杆菌致病机制、快速诊断和新型药物研究”,2009.6–2011.05,资助金额:60万。

4. 国家自然科学基金“金黄色葡萄球菌非编码小RNA的功能解析”,2010.01–2012.12,资助金额:40万。

5. 国家自然科学基金“金黄色葡萄球菌KdpDE二元信号转导系统对致病性的调控研究”,2011.01–2013.12,资助金额:34万。

近期论文:

Xiong, M., Y. Bao, X. Yang, Y. Wang, B. Sun, and J. Wang (2012). Lipase-sensitive polymeric triple-layered nanogel for "on-demand" drug delivery.

J. Am. Chem. Soc

. 134:4355-4362.

Xue, T., Y. You, F. Shang, and B. Sun (2012). Rot and Agr system modulate fibrinogen-binding ability mainly by regulatingclfB expression inStaphylococcus aureus NCTC8325.

Med. Microbiol. Immunol.

201:81-92.

Xue, T., Y. You, D. Hong, H. Sun, and B. Sun (2011). TheStaphylococcus aureus KdpDE two-component system couples extracellular K sensing and Agr signaling to infection programming.

Infect. Immun.

79:2154-2167.

Zhao, L., T. Xue, F. Shang, H. Sun, and B. Sun (2010).Staphylococcus aureus AI-2 quorum sensing associates with the KdpDE two-component system to regulate capsular polysaccharide synthesis and virulence.

Infect. Immun.

78:3506-3515.

Tao, L., X. Wu, and B. Sun (2010). Alternative sigma factor σ modulates prophage integration and excision inStaphylococcus aureus.

PLoS Pathog.

6:e1000888.

Shang, F., T. Xue, H. Sun, L. Xing, S. Zhang, Z. Yang, L. Zhang, and B. Sun (2009). TheStaphylococcus aureus GGDEF domain-containing protein, GdpS, influences protein A gene expression in a cyclic diguanylic acid-independent manner.

Infect. Immun.

77:2849-2856.

Huang, J., B. Sun, and X. Zhang (2010).Shewanella xiamenensis sp. nov., isolated from coastal sea sediment.

Int. J. Syst. Evol. Microbiol

. 60:1585-1589.

Huang, J., B. Sun, and X. Zhang (2010). Electricity generation at high ionic strength in microbial fuel cell by a newly isolatedShewanella marisflavi EP1.

Appl. Microbiol. Biotechnol

. 85:1141-1149.

Xue, T., L. Zhao, H. Sun, X. Zhou, and B. Sun (2009). LsrR binding-site recognition and regulatory characteristics inEscherichia coli AI-2 quorum sensing.

Cell Res.

19:1258-1268.

Wu, C. and B. Sun (2009). Identification of novel esterase from metagenomic library of Yangtze River.

J. Microbiol. Biotechnol.

19:187-193.

Chu, X., H. He, C. Guo, and B. Sun (2008). Identification of two novel esterases from a marine metagenomic library derived from South China Sea.

Appl. Microbiol. Biotechnol.

80:615-625.

Zhou, X., X. Meng, and B. Sun (2008). An EAL domain protein and cyclic AMP contribute to the interaction between the two quorum sensing systems inEscherichia coli.

Cell Res.

18:937-948.

Ju, X., L. Zhao, and B. Sun (2007). Nitrogen fixation by reductively dechlorinating bacteria.

Environ. Microbiol.

9:1078-1083.

Sun, B., B. M. Griffin, H. L. Ayala-del-Río, S. A. Hashsham, and J. M. Tiedje (2002). Microbial dehalorespiration with 1,1,1-trichloroethane.

Science

298:1023-1025.

Sun, B., J. R. Cole, and J. M. Tiedje (2001).Desulfomonile limimaris sp. nov., an anaerobic dehalogenating bacterium from marine sediments.

Int. J. Syst. Evol. Microbiol.

51:365-371.

Sun, B., J. R. Cole, R. A. Sanford, and J. M. Tiedje (2000). Isolation and characterization ofDesulfovibrio dechloracetivorans sp. nov., a marine dechlorinating bacterium growing by coupling the oxidation of acetate to the reductive dechlorination of 2-chlorophenol.

Appl. Environ. Microbiol.

66:2408-2413.

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